Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury
نویسندگان
چکیده
منابع مشابه
Developing Extracellular Matrix Technology to Treat Retinal or Optic Nerve Injury1,2,3
Adult mammalian CNS neurons often degenerate after injury, leading to lost neurologic functions. In the visual system, retinal or optic nerve injury often leads to retinal ganglion cell axon degeneration and irreversible vision loss. CNS axon degeneration is increasingly linked to the innate immune response to injury, which leads to tissue-destructive inflammation and scarring. Extracellular ma...
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Retinal ischemia occurs in a variety of eye diseases. Restrained blood flow induces retinal damage, which leads to progressive optic nerve degeneration and vision loss. Previous studies indicate that extracellular matrix (ECM) constituents play an important role in complex tissues, such as retina and optic nerve. They have great impact on de- and regeneration processes and represent major candi...
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The presence and distribution of laminin, heparan sulfate proteoglycan and collagen types I, III and IV were immunohistologically determined in cynomolgus monkey optic nerve heads using the avidin-biotin-peroxidase complex technique. Collagen types I and III were detected within the collagenous plates of the scleral lamina cribrosa, in the septa and pia mater of the postlaminar optic nerve and ...
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CASE REPORTS We present two cases of blunt ocular trauma with clinical findings and complementary tests compatible with traumatic optic neuropathy (TON), and progression to sectorial optic atrophy. DISCUSSION TON have an essentially clinical diagnosis, and in the last few years has been treated with high doses of intravenous steroids, based on weak evidence of the benefit of the steroids in c...
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G optic neuritis is still somewhat of a management puzzle for ophthalmologists despite two excellent studies in recent years, says Anthony C. Arnold, MD, Professor of Ophthalmology, Chief of the Division of Neuro-Ophthalmology, and Director of the Optic Neuropathy Center at the Jules Stein Eye Institute. “Whether to treat typical monosymptomatic optic neuritis with steroids or not has always be...
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ژورنال
عنوان ژورنال: eneuro
سال: 2015
ISSN: 2373-2822
DOI: 10.1523/eneuro.0077-15.2015